Pair Name	Capsaicin, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	EGFR	hsa1956
	Up-regulation	Expression	PARP1	hsa142
In Vitro Model	LM3	Malignant neoplasms of the mouse mammary gland	Mus musculus (Mouse)	CVCL_D269
	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0336
In Vivo Model	Five-week-old BALB/C nude mice received a subcutaneous injection of 1×10⁷ LM3 cells suspended in 100 uL sterile PBS into the right flank.
Result	These data confirm that capsaicin and sorafenib combination treatment inhibits the growth, invasion and metastasis of HCC cells and induces autophagy in a synergistic manner, supporting its potential as a therapeutic option for HCC.